signal recognition particle-receptor

signal recognition particle-receptor
Receptor for the signal recognition particle (SRP) found in the membrane of the endoplasmic reticulum. Also known as docking protein. Heterodimeric, both protomers having GTP-binding capacity, though dissimilar binding sites. Not until the complex of SRP, ribosome, message, and nascent polypeptide chain binds to the SRP-receptor is the block to further chain elongation released - and concurrently the SRP is released, leaving the ribosome attached to the ER membrane. Co-translational transport of the polypeptide delivers it into the lumen of the ER.

Dictionary of molecular biology. 2004.

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  • docking protein — See signal recognition particle receptor …   Dictionary of molecular biology

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